Homogeneous Hydrogenation
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Homogeneous hydrogenation is one of the most thoroughly studied fields of homogeneous catalysis. The results of these studies have proved to be most important for an understanding of the underlying principles of the activation of small molecules by transition metal complexes. During the past three decades homogeneous hydrogenation has found widespread application in organic chemistry, including the production of important pharmaceuticals, especially where a sophisticated degree of selectivity is required. This volume presents a general account of the main principles and applications of homogeneous hydrogenation by transition metal complexes. Special attention is devoted to the mechanisms by which these processes occur, and the role of the recently discovered complexes of molecular hydrogen is described. Sources of hydrogen, other than H2, are also considered (transfer hydrogenation). The latest achievements in highly stereoselective hydrogenations have made possible many new applications in organic synthesis. These applications are documented by giving details of the reduction of important unsaturated substrates (alkenes, alkynes, aldehydes and ketones, nitrocompounds, etc.). Hydrogenation in biphasic and phase transfer catalyzed systems is also described. Finally, a discussion of the biochemical routes of H2 activation highlights the similarities and differences in performing hydrogenation in both natural and synthetic systems. For researchers working in the fields of homogeneous catalysis, especially in areas such as pharmaceuticals, plastics and fine chemicals. Booknews Presents a general account of the main principles and applications of homogeneous hydrogenation by transition metal complexes. Following a brief introduction, six chapters address the mechanisms for homogeneous hydrogenation; homogeneous transfer hydrogenation catalyzed by metal complexes; homogeneous hydrogenation in organic synthesis; hydrogenation in aqueous systems; supported metal complexes; and hydrogen activation in biological systems. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Foreword1Introduction12The mechanisms of homogeneous hydrogenation53Homogeneous transfer hydrogenation catalysed by metal complexes874Homogeneous hydrogenation in organic synthesis1195Hydrogenation in aqueous systems1836Supported metal complexes2417Hydrogen activation in biological systems255Abbreviations271Index275
